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Protein S is part of a system that prevents excessive blood clots. Protein C and Protein S, complementing and strengthening each other, adjust the rate of blood clot formation so that blood clots form only at the site of injury. In the case where the activity or concentration of proteins is normal, the regulation of coagulation also works well.
The test examines the cause of the thrombotic event. It can be used to determine if the patient has inherited or acquired Protein S deficiency.

In case of thromboembolism (called deep vein thrombosis and pulmonary embolism) of unknown origin or if the patient’s newborn has a severe coagulation disorder or a close relative has been diagnosed with an inherited Protein S deficiency.
A test for decreased Protein S activity should be performed again prior to diagnosis, as conditions may occur that may temporarily alter the level or function of the protein.

Plasma is required for the test. A blood sample taken in a citrate tube is ideal for extraction as citrate prevents clotting. After drawing blood, the blood in the tube is circulated so that the anticoagulant can work properly.
Elevated Protein S levels are mostly not associated with health problems. Decreased protein levels can occur following severe infection, vitamin K deficiency, liver and kidney disease, cancer, and thrombotic events.
In all cases, please consult the specialist or internist who ordered the test with the result.
Informational content only The textual content published on this page is for general information purposes only and does not constitute medical advice, a diagnosis, or a treatment recommendation. Proper assessment, examination, and therapeutic decisions always require a personal medical consultation and, where appropriate, further specialist opinion. Medicare Egészségközpont Zrt. makes every reasonable effort to keep the content up to date; however, it accepts no liability for the completeness or accuracy of the information published or for consequences arising from decisions based on it.